Nootrobox

Name: Nootrobox
Brand: H.V.M.N.
Price: 109.95 USD
Availability: InStock

(0)

Supplements to Support Brain and Body Function

Nootrobox is a system of four nootropic blends designed to provide energy & focus, improve memory, protect your brain and body, and improve sleep quality.

Nootrobox

(0)

Supplements to Support Brain and Body Function

Nootrobox is a system of four nootropic blends designed to provide energy & focus, improve memory, protect your brain and body, and improve sleep quality.

$98.96

Select Quantity

Single

2 Pack

3 Pack

Subscribe monthly & save 10%

$98.96/mo

One-time order

$109.95

Shipping is included for orders over $50.

Nootrobox

Buy Now

What's Inside?

I. Long-Term Investment for Brain & Body.

Rise

Daily Nootropic For Memory

MemoryAnxiety & StressMental Resilience

Rise is a daily nootropic stack for your brain and mind–supporting memory, mood, and long-term cognitive resilience. It can help enhance memory, reduce anxiety and stress, and promote healthy brain function. Rise took Silicon Valley by storm and has been featured in top business and technology press including Wall Street Journal, Bloomberg and Business Insider, which discuss how it can help with memory, mental resilience, anxiety and mental fatigue.

Learn more

Ingredients

Serving size: 2 capsules. Servings per container: 30

Bacopa Monnieri

300 mg

Derived from a perennial creeping herb leaf and used in traditional Ayurvedic medicine for thousands of years

Our plant extract is one of the purest available, standardized to 50% bacosides concentration, matching the potencies in clinical trials

Long term use can improve memory when taken regularly for at least eight weeks¹^,²^,³^,⁴^,⁵

Long term use can decrease anxiety¹^,⁶

Ashwagandha

250 mg

Herb root extract used in traditional Ayurvedic medicine, acting as an adaptogen (a natural substance considered to help the body adapt to stress)

Our plant extract is one of the purest available, standardized to 10% withanolides.

Can help reduce feelings of stress⁷^,⁸^,⁹ and anxiety¹⁰^,¹¹

Lowers the levels of the stress hormone cortisol¹⁰

CDP Choline (Citicoline)

250 mg

Ultra-effective choline precursor to the vital neurotransmitter acetylcholine

Helps to protect the integrity of neuron structure and function¹²^,¹³^,¹⁴

Can contribute to improved memory¹⁵^,¹⁶

Kado

Daily Omega-3 Healthkit

Bone & Cardiovascular HealthAnti-InflammatoryMemory

Kado is a daily-use blend of essential building blocks, designed to optimize and protect your brain and body. Ingredients present in Kado may improve mood and aid in stress reduction, and for athletes, improve cardiovascular health. Together, these can help promote a robust mind and healthy physiology. Studies suggest the benefits of Kado accrue with daily, consistent use over time.

Learn more

Ingredients

Serving size: 2 capsules. Servings per container: 30

Omega-3

470 mg DHA, 235 mg EPA

Found in fish and krill oil, Omega-3 acts as a signal in the body and as the building blocks of cell membranes

Omega-3 fatty acids in Kado help the absorption of fat soluble vitamins (D & K)

The main types of Omega-3 fatty acids derived from animal sources are EPA (signaler to help reduce inflammation), DHA (promotes fluidity at synaptic junctions, where memories are formed in neural networks)

Kado contains a high 2:1 ratio of DHA:EPA for cognitive health

Improve memory and reaction time¹⁷^,¹⁸^,¹⁹

Supplementation has many other benefits for cardiovascular and metabolic health

Can reduce depression²⁰

Shown to improve attention, executive function, and memory¹⁹^,¹⁷^,¹⁸

Protective against cognitive decline²¹

Helps reduce inflammation and soreness after exercise²²^,²³^,²⁴^,²⁵

Vitamin D3

2000 IU

Produced naturally from cholesterol provided there is enough sunlight

Due to indoor lifestyle, an estimated 75% of Americans are deficient in vitamin D²⁶

Vitamin D deficiency is associated with an increased risk of depressed mood and of neurodegenerative disease in old age²⁷^,²⁸^,²⁹^,³⁰

Lower levels correlate with depression, increased rates of cognitive impairment and increased risk of neurodegenerative disease²⁸^,²⁹^,³¹

May decrease the risk of cardiovascular disease³¹

Promotes strong muscle and healthy bones³²^,³³

Can improve muscle strength and function³⁴^,³⁵

Vitamin K1 & K2

500 mcg K1, 100 mcg K2

Vitamers of vitamin K, an essential dietary micronutrient deficient in modern diets³⁶

Essential cofactors for the production of neural cell membranes and optimal bone health³⁷

Supplementation improves bone health³⁸^,³⁹^,⁴⁰

Kado contains Menaquinone-7 (MK-7), a highly bioavailable vitamer, which gives more stable vitamin K levels that build up with supplementation⁴¹

May reduce coronary artery calcification which is associated with a reduced risk for coronary heart disease⁴²^,⁴³

Required for the production of ‘sphingolipids’ which play an important structural role in neuron cell membranes⁴⁴

Astaxanthin

2 mg

Naturally occurring carotenoid compound that can be found in algae, shrimp, lobster, crab, and salmon

Antioxidant⁴⁵^,⁴⁶^,⁴⁷^,⁴⁸

Anti-inflammatory⁴⁹^,⁵⁰^,⁵¹

Potentially protective against neurodegenerative disease⁵²

II. Short-Term Cognitive Boost.

Sprint

Nootropic For Energy and Focus

FocusEnergyClarity

Sprint is a nootropic stack designed to promote alertness, focus, and relaxation–putting you into the ideal mental flow state to get the job done. Sprint can help improve attention, provide jitter-free energy and decrease fatigue to keep your mind on its toes.

Learn more

Ingredients

Serving size: 2 capsules. Servings per container: 30

Caffeine

200 mg

Most widely used and scientifically-supported psychoactive substance in the world⁵³

Caffeine, derived from xanthine, is one of the most robust nootropics available; caffeine can improve sustained attention, alertness, and working memory⁵⁴^,⁵⁵^,⁵⁶^,⁵⁷^,⁵⁸^,⁵⁹^,⁶⁰

Promotes wakefulness⁵⁵

Improves several markers of cognitive performance in healthy young adults⁵⁴^,⁵⁶^,⁵⁸^,⁶⁰

Reliably enhances endurance up to 12%⁶¹

L-Theanine

200 mg

Amino acid commonly found in tea⁶²

Promotes relaxation without sedation

Shown to reverse the blood pressure and cerebral vascular restriction caused by caffeine intake⁶³^,⁶⁴

Shown to reduce stress and anxiety⁶⁵^,⁶⁶^,⁶⁷^,⁶⁸

Caffeine & L-Theanine Synergies

Caffeine + L-theanine have synergistic effects on cognition–meaning that together, they produce cognitive benefits not seen when either is used alone

Mitigate the increased cerebral blood pressure caused by caffeine alone⁶⁹^,⁶³^,⁶⁴

Improve performance in tests of word recognition, rapid visual information processing, attention, as well as mood⁷⁰^,⁷¹^,⁷²

Ginseng

400 mg

A stem and leaf extract used in traditional medicine for centuries

Our plant extract is one of the purest available, standardized to 5% ginsenosides

Helps cognitive performance by reducing the impact of fatigue⁷³^,⁷⁴^,⁷⁵^,⁷⁶

Helps mood⁷³ by promoting calmness⁷⁴ and tranquility

Improves simple reaction time⁵

III. Optimized Sleep Health.

Yawn

Rejuvenating Sleep Aid

SleepMoodStress

Yawn is a non-habit-forming sleep aid to support every facet of healthy sleep, so every night can be your best night’s sleep. It can help you fall asleep easier, improve sleep quality and wake up feeling refreshed. Sufficient, high-quality sleep is scientifically agreed upon to be the one of the most important pillars to optimizing cognition and physical performance in the near-term.

Learn more

Ingredients

Serving size: 1 capsules. Servings per container: 30

Magnesium Glycinate

250 mg

Magnesium is an essential dietary mineral, and the second most prevalent electrolyte in the human body

Magnesium deficiency is common in the United States, with an estimated 68% of the population not meeting the FDA recommended daily intake of magnesium⁷⁷^,⁷⁸^,⁷⁹

The glycinate form adds bioavailability of magnesium and additional glycine content⁸⁰

Supplementing as magnesium glycinate increases the bioavailability of magnesium and provides additional glycine⁸¹

Magnesium is linked to reduced markers of inflammatory stress and improved sleep quality⁷⁹^,⁸²

L-Glycine

500 mg

Amino acid and a neurotransmitter

Improves subjective sensation of sleep quality and mood on waking⁷⁷^,⁸³

Reduces time to fall asleep⁸⁴

Improved cognitive performance the next day⁸⁵

L-Theanine

100 mg

Amino acid commonly found in tea⁶²

Reduces stress and anxiety⁶⁵^,⁶⁶^,⁶⁷^,⁶⁸

Shown to reverse the blood pressure and constriction of brain vessels caused by caffeine intake⁶³^,⁶⁴

Melatonin

1 mg

Hormone produced in the brain that promotes sleep and regulates circadian rhythm (sleep-wake cycle)⁸⁶

1 mg of melatonin not habit-forming⁸⁷^,⁸⁸

Reduces the time to fall asleep and improves sleep quality⁸⁹^,⁹⁰

Helps to normalise the sleep-wake cycle after travel across time zones⁹¹

Neuroprotective due to antioxidant and antiinflammatory properties⁹²

H.V.M.N. has the dedication and does the research to find and make supplements that can truly aid humans in their quest to be better.

Nate Hart

Supplements designed to optimize the spectrum of performance.

Maintaining and improving performance is a long-term investment. Our supplements are developed by blending compounds in specific dosages to work together. The brain is and body are sophisticated, so we need to be dynamic in how we nourish and protect them.

A radar chart showing a high effect on stress reduction and working memory, and a moderate affect on mood and focus.

A radar chart showing a high effect on mood and health, and a moderate effect on stress reduction and working memory.

A radar chart showing a high effect on focus and working memory, and a moderate effect on stress reduction and mood.

A radar chart showing a high effect on sleep, and moderate effects on stress reduction, mood, and working memory.

Rise

Kado

Sprint

Yawn

After roughly a week on the full @nootrobox stack, I couldn't recommend it enough. Feel sharp, alert, and just... positive?

Paul unr Morrison

All Customer Reviews

Be the first to review this product.

Write a Review

Scientific Citations

1. Stough, C., Lloyd, J., Clarke, J., Downey, L. A., Hutchison, C. W., Rodgers, T., & Nathan, P. J. (2001). The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl), 156(4), 481-484.

2. Stough C., Downey L. A., Lloyd J., et al. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. Phytother Res. 2008. 22(12), 1629-34

3. Pase M. P., Kean J., Sarris J., Neale C., Scholey A. B., Stough C. The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. J Altern Complement Med. 2012. 18(7), 647-52

4. Raghav, S., Singh, H., Dalal, P. K., Srivastava, J. S., & Asthana, O. P. (2006). Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment. Indian J Psychiatry, 48(4), 238-242. doi:10.4103/0019-5545.31555

5. Neale, C., Camfield, D., Reay, J., Stough, C., & Scholey, A. (2013). Cognitive effects of two nutraceuticals Ginseng and Bacopa [...]: a review and comparison of effect sizes. British Journal of Clinical Pharmacology, 75(3), 728-737. doi:10.1111/bcp.12002

6. Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. Effects of a Standardized Bacopa monnieri Extract on Cognitive Performance, Anxiety, and Depression in the Elderly: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of Alternative and Complementary Medicine. 2008;14(6):707-713. doi:10.1089/acm.2008.0018.

7. Cooley K. , Szczurko O., Perri D, et al. Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974. PLoS ONE. 2009. 4(8), e6628.

8. Auddy B., Hazra J., Mitra A., et al. A Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled Study. JANA. 2008. (11) 1.

9. Andrade C., Aswath A., Chaturvedi S. K., Srinivasa M., Raguram R. A double-blind, placebo-controlled evaluation of the anxiolytic efficacy ff an ethanolic extract of withania somnifera. Indian J Psychiatry. 2000. 42(3), 295-301.

10. Chandrasekhar K., Kapoor J., Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012. 34(3), 255-62

11. Pratte M. A., Nanavati K. B., Young V., Morley C. P. An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). J Altern Complement Med. 2014 Dec. 20(12), 901-8. doi: 10.1089/acm.2014.0177.

12. Babb S. M., Wald L. L., Cohen B. M., Villafuerte R. A., Gruber S. A., Yurgelun-Todd D. A., Renshaw P. F. Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study. Psychopharmacology (Berl). 2002 May. 161(3), 248-54. Epub 2002 Mar 22.

13. Saver J. L. Citicoline: update on a promising and widely available agent for neuroprotection and neurorepair. Rev Neurol Dis. 2008. 5(4), 167-77.

14. Fioravanti M., Yanagi M. Cytidinediphosphocholine (CDP choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. Cochrane Database Syst Rev. 2004. (2), CD000269.

15. McGlade E., Locatelli A., Hardy J., et al. Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women. Food and Nutrition Sciences, 2012, 3, 769-773

16. Mcglade E., Agoston A. M., Dimuzio J, et al. The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males. J Atten Disord. 2015.

17. Narendran R, Frankle WG, Mason NS, Muldoon MF, Moghaddam B (2012) Improved Working Memory but No Effect on Striatal Vesicular Monoamine Transporter Type 2 after Omega-3 Polyunsaturated Fatty Acid Supplementation. PLoS ONE 7(10): e46832

18. Stonehouse W, Conlon CA, Podd J. DHA supplementation improved both memory and reaction time in healthy young adults: a randomized controlled trial. The American journal of clinical nutrition. 2013; 97(5):1134-43.

19. Fontani, G., Corradeschi, F., Felici, A., Alfatti, F., Migliorini, S., & Lodi, L. (2005). Cognitive and physiological effects of Omega-3 polyunsaturated fatty acid supplementation in healthy subjects. Eur J Clin Invest, 35(11), 691-699. doi:10.1111/j.1365-2362.2005.01570.x

20. Martins JG. EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials. Journal of the American College of Nutrition. 2009; 28(5):525-42.

21. Muldoon MF, Ryan CM, Sheu L, Yao JK, Conklin SM, Manuck SB. Serum phospholipid docosahexaenonic acid is associated with cognitive functioning during middle adulthood. The Journal of nutrition. 2010; 140(4):848-53.

22. Simopoulos, A. P. Omega-3 fatty acids and athletics. Curr Sports Med Rep. 2007 Jul. 6(4), 230-6.

23. Corder K. E., Newsham K. R., Mcdaniel J. L., Ezekiel U. R., Weiss E. P. Effects of Short-Term Docosahexaenoic Acid Supplementation on Markers of Inflammation after Eccentric Strength Exercise in Women. J Sports Sci Med. 2016. 15(1), 176-83.

24. Jouris K. B., Mcdaniel J. L., Weiss E. P. The Effect of Omega-3 Fatty Acid Supplementation on the Inflammatory Response to eccentric strength exercise. J Sports Sci Med. 2011. 10(3), 432-8.

25. Tartibian B, Maleki BH, Abbasi A. The effects of ingestion of omega-3 fatty acids on perceived pain and external symptoms of delayed onset muscle soreness in untrained men. Clin J Sport Med. 2009 Mar. 19(2), 115-9. doi: 10.1097/JSM.0b013e31819b51b3.

26. Tangpricha, V., Pearce, E. N., Chen, T. C., & Holick, M. F. (2002). Vitamin D insufficiency among free-living healthy young adults. Am J Med, 112(8), 659-662.

27. Annweiler, C., Allali, G., Allain, P., Bridenbaugh, S., Schott, A. M., Kressig, R. W., & Beauchet, O. (2009). Vitamin D and cognitive performance in adults: a systematic review. European Journal of Neurology, 16(10), 1083-1089. doi:10.1111/j.1468-1331.2009.02755.x

28. Annweiler, C., Montero-Odasso, M., Llewellyn, D. J., Richard-Devantoy, S., Duque, G., & Beauchet, O. (2013). Meta-analysis of memory and executive dysfunctions in relation to vitamin D. J Alzheimers Dis, 37(1), 147-171. doi:10.3233/jad-130452

29. Balion, C., Griffith, L. E., Strifler, L., Henderson, M., Patterson, C., Heckman, G., . . . Raina, P. (2012). Vitamin D, cognition, and dementia A systematic review and meta-analysis. Neurology, 79(13), 1397-1405.

30. Etgen, T., Sander, D., Bickel, H., Sander, K., & Forstl, H. (2012). Vitamin D deficiency, cognitive impairment and dementia: a systematic review and meta-analysis. Dement Geriatr Cogn Disord, 33(5), 297-305. doi:10.1159/000339702

31. Wang L, Manson JE, Song Y, Sesso HD. Systematic review: Vitamin D and calcium supplementation in prevention of cardiovascular events. Annals of internal medicine. 2010; 152(5):315-23.

32. Burgi A. A., Gorham E. D., Garland C. F., Mohr S. B., Garland F. C., Zeng K., Thompson K., Lappe J. M. High serum 25-hydroxyvitamin D is associated with a low incidence of stress fractures. J Bone Miner Res. 2011 Oct. 26(10), 2371-7. doi: 10.1002/jbmr.451.

33. Matsumoto T, Igarashi C, Takeuchi Y. Stimulation by 1,25-dihydroxyvitamin D3 of in vitro mineralization induced by osteoblast-like MC3T3-E1 cells. Bone. 1991; 12(1):27-32.

34. Rejnmark L. Effects of vitamin d on muscle function and performance: a review of evidence from randomized controlled trials. Ther Adv Chronic Dis. 2011. 2(1), 25-37.

35. Ceglia L. Vitamin D and its role in skeletal muscle. Curr Opin Clin Nutr Metab Care. 2009. 12(6), 628-33.

36. Prynne, C. J., Thane, C. W., Prentice, A., & Wadsworth, M. E. (2005). Intake and sources of phylloquinone (vitamin K(1)) in 4-year-old British children: comparison between 1950 and the 1990s. Public Health Nutr, 8(2), 171-180.

37. Ferland, G. (2012). Vitamin K and the nervous system: an overview of its actions. Adv Nutr, 3(2), 204-212. doi:10.3945/an.111.001784

38. Hao G, Zhang B, Gu M. Vitamin K intake and the risk of fractures: A meta-analysis. Medicine. 2017; 96(17):e6725.

39. Fang Y, Hu C, Tao X, Wan Y, Tao F. Effect of vitamin K on bone mineral density: a meta-analysis of randomized controlled trials. Journal of bone and mineral metabolism. 2012; 30(1):60-8.

40. Braam LA, Knapen MH, Geusens P. Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age. Calcified tissue international. 2003; 73(1):21-6.

41. Schurgers LJ, Teunissen KJ, Hamulyák K, Knapen MH, Vik H, Vermeer C. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. 2007; 109(8):3279-83.

42. Beulens, J. W., Bots, M. L., Atsma, F., Bartelink, M. L., Prokop, M., Geleijnse, J. M., . . . van der Schouw, Y. T. (2009). High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis, 203(2), 489-493. doi:10.1016/j.atherosclerosis.2008.07.010

43. Geleijnse, J. M., Vermeer, C., Grobbee, D. E., Schurgers, L. J., Knapen, M. H., van der Meer, I. M., . . . Witteman, J. C. (2004). Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr, 134(11), 3100-3105.

44. Carrié I, Portoukalian J, Vicaretti R, Rochford J, Potvin S, Ferland G. Menaquinone-4 concentration is correlated with sphingolipid concentrations in rat brain. The Journal of nutrition. 2004; 134(1):167-72.

45. Kobayashi, M. & Sakamoto, Y. Biotechnology Letters (1999) 21: 265.

46. Chitchumroonchokchai C, Bomser JA, Glamm JE, Failla ML. Xanthophylls and alpha-tocopherol decrease UVB-induced lipid peroxidation and stress signaling in human lens epithelial cells. The Journal of nutrition. 2004; 134(12):3225-32.

47. Choi H. D., Youn Y. K., Shin W. G. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011. 66(4), 363-9.

48. Choi H. D., Kim J. H., Chang M. J., Kyu-youn Y., Shin W. G. Effects of astaxanthin on oxidative stress in overweight and obese adults. Phytother Res. 2011. 25(12), 1813-8.

49. Lee SJ, Bai SK, Lee KS. Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation. Molecules and cells. 2003; 16(1):97-105.

50. Ohgami K, Shiratori K, Kotake S. Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Investigative ophthalmology & visual science. 2003; 44(6):2694-701.

51. Nakano M, Onodera A, Saito E. Effect of astaxanthin in combination with alpha-tocopherol or ascorbic acid against oxidative damage in diabetic ODS rats. Journal of nutritional science and vitaminology. 2008; 54(4):329-34.

52. Hussein G, Nakamura M, Zhao Q. Antihypertensive and neuroprotective effects of astaxanthin in experimental animals. Biological & pharmaceutical bulletin. 2005; 28(1):47-52.

53. Fredholm, B. B., Battig, K., Holmen, J., Nehlig, A., & Zvartau, E. E. (1999). Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev, 51(1), 83-133.

54. Einother, S. J., & Giesbrecht, T. (2013). Caffeine as an attention enhancer: reviewing existing assumptions. Psychopharmacology (Berl), 225(2), 251-274. doi:10.1007/s00213-012-2917-4

55. Johnson, L. C., Spinweber, C. L., & Gomez, S. A. (1990). Benzodiazepines and caffeine: effect on daytime sleepiness, performance, and mood. Psychopharmacology (Berl), 101(2), 160-167.

56. Smith, A. P., Kendrick, A. M., & Maben, A. L. (1992). Effects of breakfast and caffeine on performance and mood in the late morning and after lunch. Neuropsychobiology, 26(4), 198-204. doi:118920

57. Smith, B. D., Davidson, R. A., & Green, R. L. (1993). Effects of caffeine and gender on physiology and performance: further tests of a biobehavioral model. Physiol Behav, 54(3), 415-422.

58. Smith, A., Kendrick, A., Maben, A., & Salmon, J. (1994). Effects of breakfast and caffeine on cognitive performance, mood and cardiovascular functioning. Appetite, 22(1), 39-55. doi:10.1006/appe.1994.1004

59. Warburton, D. M. (1995). Effects of caffeine on cognition and mood without caffeine abstinence. Psychopharmacology (Berl), 119(1), 66-70.

60. Wilhelmus, M. M., Hay, J. L., Zuiker, R. G., Okkerse, P., Perdrieu, C., Sauser, J., . . . Silber, B. Y. (2017). Effects of a single, oral 60 mg caffeine dose on attention in healthy adult subjects. J Psychopharmacol, 31(2), 222-232. doi:10.1177/0269881116668593

61. Doherty M., Smith P. M. Effects of caffeine ingestion on exercise testing: a meta-analysis. Int J Sport Nutr Exerc Metab. 2004. 14(6), 626-46.

62. Borzelleca, J. F., Peters, D., & Hall, W. (2006). A 13-week dietary toxicity and toxicokinetic study with l-theanine in rats. Food Chem Toxicol, 44(7), 1158-1166. doi:10.1016/j.fct.2006.03.014

63. Dodd, F. L., Kennedy, D. O., Riby, L. M., & Haskell-Ramsay, C. F. (2015a). A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and mood. Psychopharmacology (Berl), 232(14), 2563-2576. doi:10.1007/s00213-015-3895-0

64. Rogers, P. J., Smith, J. E., Heatherley, S. V., & Pleydell-Pearce, C. W. (2008). Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together. Psychopharmacology (Berl), 195(4), 569-577. doi:10.1007/s00213-007-0938-1

65. Kimura, K., Ozeki, M., Juneja, L. R., & Ohira, H. (2007). L-Theanine reduces psychological and physiological stress responses. Biol Psychol, 74(1), 39-45. doi:10.1016/j.biopsycho.2006.06.006

66. Tian, X., Sun, L., Gou, L., Ling, X., Feng, Y., Wang, L., . . . Liu, Y. (2013). Protective effect of l-theanine on chronic restraint stress-induced cognitive impairments in mice. Brain Res, 1503, 24-32. doi:10.1016/j.brainres.2013.01.048

67. Unno, K., Fujitani, K., Takamori, N., Takabayashi, F., Maeda, K., Miyazaki, H., . . . Hoshino, M. (2011). Theanine intake improves the shortened lifespan, cognitive dysfunction and behavioural depression that are induced by chronic psychosocial stress in mice. Free Radic Res, 45(8), 966-974. doi:10.3109/10715762.2011.566869

68. Unno, K., Tanida, N., Ishii, N., Yamamoto, H., Iguchi, K., Hoshino, M., . . . Yamada, H. (2013). Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary alpha-amylase activity, trait anxiety and subjective stress. Pharmacol Biochem Behav, 111, 128-135. doi:10.1016/j.pbb.2013.09.004

69. Caldenhove, S., Sambeth, A., Sharma, S. et al. J Cogn Enhanc (2017).

70. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., & Scholey, A. B. (2008). The effects of L-theanine, caffeine and their combination on cognition and mood. Biol Psychol, 77(2), 113-122. doi:10.1016/j.biopsycho.2007.09.008

71. Giesbrecht, T., Rycroft, J. A., Rowson, M. J., & De Bruin, E. A. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutr Neurosci, 13(6), 283-290. doi:10.1179/147683010x12611460764840

72. Kahathuduwa, C. N., Dassanayake, T. L., Amarakoon, A. M., & Weerasinghe, V. S. (2016). Acute effects of theanine, caffeine and theanine-caffeine combination on attention. Nutr Neurosci. doi:10.1080/1028415x.2016.1144845

73. Ellis J. M., Reddy P. Effects of Panax ginseng on quality of life. Ann Pharmacother. 2002. 36(3), 375-9.

74. Reay J. L., Scholey A. B., Kennedy D. O. Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults. Hum Psychopharmacol. 2010. 25(6), 462-71.

75. Reay J. L., Kennedy D. O., Scholey A. B. Effects of Panax ginseng, consumed with and without glucose, on blood glucose levels and cognitive performance during sustained 'mentally demanding' tasks. J Psychopharmacol (Oxford). 2006. 20(6), 771-81.

76. Reay J. L., Kennedy D. O., Scholey A. B. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Psychopharmacol (Oxford). 2005. 19(4), 357-65.

77. Inagawa, K., Hiraoka, T., Kohda, T., Yamadera, W., & Takahashi, M. (2006). Subjective effects of glycine ingestion before bedtime on sleep quality. Sleep and Biological Rhythms, 4(1), 75-77. doi:10.1111/j.1479-8425.2006.00193.x

78. Murck, H., & Steiger, A. (1998). Mg2+ reduces ACTH secretion and enhances spindle power without changing delta power during sleep in men -- possible therapeutic implications. Psychopharmacology (Berl), 137(3), 247-252.

79. Nielsen, F. H., Johnson, L. K., & Zeng, H. (2010). Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep. Magnes Res, 23(4), 158-168. doi:10.1684/mrh.2010.0220

80. Deng, X., Song, Y., Manson, J. E., Signorello, L. B., Zhang, S. M., Shrubsole, M. J., . . . Dai, Q. (2013). Magnesium, vitamin D status and mortality: results from US National Health and Nutrition Examination Survey (NHANES) 2001 to 2006 and NHANES III. BMC Med, 11(1), 187. doi:10.1186/1741-7015-11-187

81. Schuette SA, Lashner BA, Janghorbani M. Bioavailability of magnesium diglycinate vs magnesium oxide in patients with ileal resection. JPEN. Journal of parenteral and enteral nutrition. ; 18(5):430-5.

82. Held K, Antonijevic I. A., Künzel H., Uhr M., Wetter T. C., Golly I. C., Steiger A., Murck H. Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans. Pharmacopsychiatry. 2002 Jul. 35(4), 135-43.

83. Yamadera, W., Inagawa, K., Chiba, S., Bannai, M., Takahashi, M., & Nakayama, K. (2007). Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes. Sleep and Biological Rhythms, 5(2), 126-131. doi:10.1111/j.1479-8425.2007.00262.x

84. Kunz, D., Mahlberg, R., Müller, C., Tilmann, A., & Bes, F. (2004). Melatonin in patients with reduced REM sleep duration: two randomized controlled trials. The Journal of Clinical Endocrinology & Metabolism, 89(1), 128-134.

85. Bannai, M., Kawai, N., Ono, K., Nakahara, K., & Murakami, N. (2012). The Effects of Glycine on Subjective Daytime Performance in Partially Sleep-Restricted Healthy Volunteers. Front Neurol, 3, 61. doi:10.3389/fneur.2012.00061

86. Tuli, H. S., Kashyap, D., Sharma, A. K., & Sandhu, S. S. (2015). Molecular aspects of melatonin (MLT)-mediated therapeutic effects. Life Sci, 135, 147-157. doi:10.1016/j.lfs.2015.06.004

87. Lemoine P., Nir T., Laudon M., Zisapel N. Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects. J Sleep Res. 2007 Dec. 16(4), 372-80.

88. Zhdanova I. V., Wurtman R. J., Lynch H. J, et al. Sleep‐inducing effects of low doses of melatonin ingested in the evening. Clinical Pharmacology & Therapeutics (1995) 57, 552–558.

89. Brzezinski, A., Vangel, M. G., Wurtman, R. J., Norrie, G., Zhdanova, I., Ben-Shushan, A., & Ford, I. (2005). Effects of exogenous melatonin on sleep: a meta-analysis. Sleep Med Rev, 9(1), 41-50.

90. Ferracioli-Oda, E., Qawasmi, A., & Bloch, M. H. (2013). Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders. PLoS One, 8(5), e63773. doi:10.1371/journal.pone.0063773

91. Herxheimer, A., & Petrie, K. J. (2002). Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev(2), Cd001520. doi:10.1002/14651858.cd001520

92. Koh PO. Melatonin prevents ischemic brain injury through activation of the mTOR/p70S6 kinase signaling pathway. Neuroscience letters. 2008; 444(1):74-8.

View all 92 citations

GO Cubes

Chewable Coffee

38 Mason St, 3rd Floor, San Francisco, CA 94102

Call us: 1 (855) 486-6748

Email us: care@hvmn.com

These statements have not been evaluated by the FDA. Our products are not intended to diagnose, treat, cure, or prevent any disease.

© 2019 HVMN Inc. All Rights Reserved. H.V.M.N.®, Health Via Modern Nutrition™, Nootrobox®, Rise™, Sprint®, Yawn®, Kado™, and GO Cubes® are registered trademarks of HVMN Inc. ΔG® is a trademark of TΔS® and used under exclusive license by HVMN Inc.

Help Center+

Company+

Learn+

Guides+