Nootrobox

Supplements to Support Brain and Body Function.

Nootrobox supplements are a team of four supplement stacks that can work together to optimize cognitive and physical performance. Our supplements were developed with a systems engineering methodology: enhance bodily inputs to achieve desired performance outputs. Created to support body and mind as an ecosystem, Nootrobox targets the essentials of energy, focus, memory, sleep, brain health, and metabolism.

What's Inside?

Rise - Rise is a daily nootropic stack for your brain and mind–supporting memory, mood, and long-term cognitive resilience.
Kado - Kado is a daily-use blend of essential building blocks, designed to optimize and protect your brain and body.
Sprint - Sprint is a nootropic stack designed to promote alertness, focus and relaxation–putting you in the ideal mental flow state to get the job done.
Yawn - Yawn is a non-habit-forming sleep aid to support every facet of healthy sleep, so every night can be your best night’s sleep.
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What's Inside?

I. Long-Term Investment for Brain & Body.

Rise

Daily Nootropic For Memory
MemoryAnxiety & StressMental Resilience

Rise is a daily nootropic stack for your brain and mind–supporting memory, mood, and long-term cognitive resilience. It can help enhance memory, reduce anxiety and stress, and promote healthy brain function. Rise took Silicon Valley by storm and has been featured in top business and technology press including Wall Street Journal, Bloomberg and Business Insider, which discuss how it can help with memory, mental resilience, anxiety and mental fatigue.

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Ingredients

Serving size: 2 capsules. Servings per container: 30

Bacopa Monnieri

300 mg

+

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Derived from a perennial creeping herb leaf and used in traditional Ayurvedic medicine for thousands of years

Our plant extract is one of the purest available, standardized to 50% bacosides concentration, matching the potencies in clinical trials

Long term use can improve memory when taken regularly for at least eight weeks1,2,3,4,5

Long term use can decrease anxiety1,6

Ashwagandha

250 mg

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-

Herb root extract used in traditional Ayurvedic medicine, acting as an adaptogen (a natural substance considered to help the body adapt to stress)

Our plant extract is one of the purest available, standardized to 10% withanolides.

Can help reduce feelings of stress7,8,9 and anxiety10,11

Lowers the levels of the stress hormone cortisol10

CDP Choline (Citicoline)

250 mg

+

-

Ultra-effective choline precursor to the vital neurotransmitter acetylcholine

Helps to protect the integrity of neuron structure and function12,13,14

Can contribute to improved memory15,16

Kado

Daily Omega-3 Healthkit
Bone & Cardiovascular HealthAnti-InflammatoryMemory

Kado is a daily-use blend of essential building blocks, designed to optimize and protect your brain and body. Ingredients present in Kado may improve mood and aid in stress reduction, and for athletes, improve cardiovascular health. Together, these can help promote a robust mind and healthy physiology. Studies suggest the benefits of Kado accrue with daily, consistent use over time.

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Ingredients

Serving size: 2 capsules. Servings per container: 30

Omega-3

470 mg DHA, 235 mg EPA

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Found in fish and krill oil, Omega-3 acts as a signal in the body and as the building blocks of cell membranes

Omega-3 fatty acids in Kado help the absorption of fat soluble vitamins (D & K)

The main types of Omega-3 fatty acids derived from animal sources are EPA (signaler to help reduce inflammation), DHA (promotes fluidity at synaptic junctions, where memories are formed in neural networks)

Kado contains a high 2:1 ratio of DHA:EPA for cognitive health

Improve memory and reaction time17,18,19

Supplementation has many other benefits for cardiovascular and metabolic health

Can reduce depression20

Shown to improve attention, executive function, and memory19,17,18

Protective against cognitive decline21

Helps reduce inflammation and soreness after exercise22,23,24,25

Vitamin D3

2000 IU

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-

Produced naturally from cholesterol provided there is enough sunlight

Due to indoor lifestyle, an estimated 75% of Americans are deficient in vitamin D26

Vitamin D deficiency is associated with an increased risk of depressed mood and of neurodegenerative disease in old age27,28,29,30

Lower levels correlate with depression, increased rates of cognitive impairment and increased risk of neurodegenerative disease28,29,31

May decrease the risk of cardiovascular disease31

Promotes strong muscle and healthy bones32,33

Can improve muscle strength and function34,35

Vitamin K1 & K2

500 mcg K1, 100 mcg K2

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Vitamers of vitamin K, an essential dietary micronutrient deficient in modern diets36

Essential cofactors for the production of neural cell membranes and optimal bone health37

Supplementation improves bone health38,39,40

Kado contains Menaquinone-7 (MK-7), a highly bioavailable vitamer, which gives more stable vitamin K levels that build up with supplementation41

May reduce coronary artery calcification which is associated with a reduced risk for coronary heart disease42,43

Required for the production of ‘sphingolipids’ which play an important structural role in neuron cell membranes44

Astaxanthin

2 mg

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Naturally occurring carotenoid compound that can be found in algae, shrimp, lobster, crab, and salmon

Antioxidant45,46,47,48

Anti-inflammatory49,50,51

Potentially protective against neurodegenerative disease52

II. Short-Term Cognitive Boost.

Sprint

Nootropic For Energy and Focus
FocusEnergyClarity

Sprint is a nootropic stack designed to promote alertness, focus, and relaxation–putting you into the ideal mental flow state to get the job done. Sprint can help improve attention, provide jitter-free energy and decrease fatigue to keep your mind on its toes.

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Ingredients

Serving size: 2 capsules. Servings per container: 30

Caffeine

200 mg

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-

Most widely used and scientifically-supported psychoactive substance in the world53

Caffeine, derived from xanthine, is one of the most robust nootropics available; caffeine can improve sustained attention, alertness, and working memory54,55,56,57,58,59,60

Promotes wakefulness55

Improves several markers of cognitive performance in healthy young adults54,56,58,60

Reliably enhances endurance up to 12%61

L-Theanine

200 mg

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-

Amino acid commonly found in tea62

Promotes relaxation without sedation

Shown to reverse the blood pressure and cerebral vascular restriction caused by caffeine intake63,64

Shown to reduce stress and anxiety65,66,67,68

Caffeine & L-Theanine Synergies

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Caffeine + L-theanine have synergistic effects on cognition–meaning that together, they produce cognitive benefits not seen when either is used alone

Mitigate the increased cerebral blood pressure caused by caffeine alone69,63,64

Improve performance in tests of word recognition, rapid visual information processing, attention, as well as mood70,71,72

Ginseng

400 mg

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A stem and leaf extract used in traditional medicine for centuries

Our plant extract is one of the purest available, standardized to 5% ginsenosides

Helps cognitive performance by reducing the impact of fatigue73,74,75,76

Helps mood73 by promoting calmness74 and tranquility

Improves simple reaction time5

III. Optimized Sleep Health.

Yawn

Rejuvenating Sleep Aid
SleepMoodStress

Yawn is a non-habit-forming sleep aid to support every facet of healthy sleep, so every night can be your best night’s sleep. It can help you fall asleep easier, improve sleep quality and wake up feeling refreshed. Sufficient, high-quality sleep is scientifically agreed upon to be the one of the most important pillars to optimizing cognition and physical performance in the near-term.

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Ingredients

Serving size: 1 capsules. Servings per container: 30

Magnesium Glycinate

250 mg

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-

Magnesium is an essential dietary mineral, and the second most prevalent electrolyte in the human body

Magnesium deficiency is common in the United States, with an estimated 68% of the population not meeting the FDA recommended daily intake of magnesium77,78,79

The glycinate form adds bioavailability of magnesium and additional glycine content80

Supplementing as magnesium glycinate increases the bioavailability of magnesium and provides additional glycine81

Magnesium is linked to reduced markers of inflammatory stress and improved sleep quality79,82

L-Glycine

500 mg

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-

Amino acid and a neurotransmitter

Improves subjective sensation of sleep quality and mood on waking77,83

Reduces time to fall asleep84

Improved cognitive performance the next day85

L-Theanine

100 mg

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-

Amino acid commonly found in tea62

Reduces stress and anxiety65,66,67,68

Shown to reverse the blood pressure and constriction of brain vessels caused by caffeine intake63,64

Melatonin

1 mg

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Hormone produced in the brain that promotes sleep and regulates circadian rhythm (sleep-wake cycle)86

1 mg of melatonin not habit-forming87,88

Reduces the time to fall asleep and improves sleep quality89,90

Helps to normalise the sleep-wake cycle after travel across time zones91

Neuroprotective due to antioxidant and antiinflammatory properties92

"
HVMN has the dedication and does the research to find and make supplements that can truly aid humans in their quest to be better.
Nate Hart

Supplements designed to optimize the spectrum of performance.

Maintaining and improving performance is a long-term investment. Our supplements are developed by blending compounds in specific dosages to work together. The brain is and body are sophisticated, so we need to be dynamic in how we nourish and protect them.

Rise
Kado
Sprint
Yawn
"
After roughly a week on the full @nootrobox stack, I couldn't recommend it enough. Feel sharp, alert, and just... positive?
Paul unr Morrison

All Customer Reviews

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Scientific Citations

1. Stough, C., Lloyd, J., Clarke, J., Downey, L. A., Hutchison, C. W., Rodgers, T., & Nathan, P. J. (2001). The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl), 156(4), 481-484.
2. Stough C., Downey L. A., Lloyd J., et al. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. Phytother Res. 2008. 22(12), 1629-34
3. Pase M. P., Kean J., Sarris J., Neale C., Scholey A. B., Stough C. The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. J Altern Complement Med. 2012. 18(7), 647-52
4. Raghav, S., Singh, H., Dalal, P. K., Srivastava, J. S., & Asthana, O. P. (2006). Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment. Indian J Psychiatry, 48(4), 238-242. doi:10.4103/0019-5545.31555
5. Neale, C., Camfield, D., Reay, J., Stough, C., & Scholey, A. (2013). Cognitive effects of two nutraceuticals Ginseng and Bacopa [...]: a review and comparison of effect sizes. British Journal of Clinical Pharmacology, 75(3), 728-737. doi:10.1111/bcp.12002
6. Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. Effects of a Standardized Bacopa monnieri Extract on Cognitive Performance, Anxiety, and Depression in the Elderly: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of Alternative and Complementary Medicine. 2008;14(6):707-713. doi:10.1089/acm.2008.0018.
7. Cooley K. , Szczurko O., Perri D, et al. Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974. PLoS ONE. 2009. 4(8), e6628.
8. Auddy B., Hazra J., Mitra A., et al. A Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled Study. JANA. 2008. (11) 1.
9. Andrade C., Aswath A., Chaturvedi S. K., Srinivasa M., Raguram R. A double-blind, placebo-controlled evaluation of the anxiolytic efficacy ff an ethanolic extract of withania somnifera. Indian J Psychiatry. 2000. 42(3), 295-301.
10. Chandrasekhar K., Kapoor J., Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012. 34(3), 255-62
11. Pratte M. A., Nanavati K. B., Young V., Morley C. P. An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). J Altern Complement Med. 2014 Dec. 20(12), 901-8. doi: 10.1089/acm.2014.0177.
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17. Narendran R, Frankle WG, Mason NS, Muldoon MF, Moghaddam B (2012) Improved Working Memory but No Effect on Striatal Vesicular Monoamine Transporter Type 2 after Omega-3 Polyunsaturated Fatty Acid Supplementation. PLoS ONE 7(10): e46832
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19. Fontani, G., Corradeschi, F., Felici, A., Alfatti, F., Migliorini, S., & Lodi, L. (2005). Cognitive and physiological effects of Omega-3 polyunsaturated fatty acid supplementation in healthy subjects. Eur J Clin Invest, 35(11), 691-699. doi:10.1111/j.1365-2362.2005.01570.x
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