Menu
Icons/Close/Hover Created with Sketch.

Effect of intermittent fasting and refeeding on insulin action in healthy men

Much of the evidence underpinning the benefits of intermittent fasting has been obtained through animals studies, as it is much easier to control the factors that might influence the results and it is also possible to sacrifice the animals to make detailed measures of the changes that occur in different organs of the body.

Therefore, this study done on healthy young males isimportant because they allow us to test if the effects seen in animals can be reproduced in humans. The hypothesis that was being tested was that intermittent fasting could increase the ability of insulin to:

  1. Trigger body glucose uptake
  2. Decrease adipose tissue lipolysis

8 healthy young men took part in this study. The intervention was 15 days, where every second day the men fasted for 20 hours (between 10pm to 6pm the next day). The subjects underwent baseline testing to look at their metabolism. A technique called a “glucose and insulin clamp’ was used to see how their bodies were metabolizing glucose. In this ‘clamp’ the investigators gave IV insulin at a fixed level (so insulin was standardized) and then varied the amount of IV glucose that they infused in order to maintain blood glucose at the pre-clamp level. They found that the glucose infusion rate was higher after the period of fasting, indicating that the body was more sensitive to the effects of insulin. They also measured the amount of glycerol (indicator of fat release) in the area around the adipocytes when the insulin infusion started. Insulin normally causes a sharp decline in the amount of glycerol present. In this study, the decline in glycerol was more rapid after fasting, indicating again, a greater sensitivity of the adipose tissue to insulin.

This is an interesting human study that is a proof-of concept that a period of regular fasting can increase the response of the body to the actions of insulin in healthy young men. More work still needs to be done with a greater number of people studied, and also people with insulin insensitivity, in order to see if this effect could help people with diabetes or metabolic syndrome.

Access Journal

Authored by Dr. Brianna Stubbs

Editors Choice

Atoms / Icons / List / Back / Black Created with Sketch.
Support
Icons/Close/Hover Created with Sketch.

Help Center

We’re on a mission to help you. Let us know how we can best assist you!

Need to get in touch?

Our team will get back to you in one business day, and often times, much faster.

(Mon-Fri, 10 AM - 5 PM PST)

Call us: 1 (833) 415-4866

Email is: care@hvmn.com

Cart
Icons/Close/Hover Created with Sketch.

Your cart is empty!

You haven't added anything to your cart yet! Go ahead and check out our products. Then you can come right back to checkout.

Shop All Products
Icons/Close/Hover Created with Sketch.

Keto Food Bar

4 Pack Sampler

1

Try our 4 pack for Free

Only pay shipping and receive a sample pack of all four Keto Food Bars flavors before your subscription starts.

2

Customize your first 12 pack

You’ll receive your first subscription pack in approximately 14 days. Be sure to let us know your favorite flavor, otherwise, our team will handpick for you. Don’t worry, we’ll send you a reminder before the order is processed.

3

Subscribe and Save

Every month you’ll receive a fresh supply of Keto Food Bars at $35.96 (includes 10% discount).

I acknowledge that I have read*

Icons/Close/Hover Created with Sketch.

We're not bots. Are you?

Add your phone number to get your confirmation code. Don't worry, we'll never send spam, just some updates, deals, and a GIF or two. Plus, if you ever need customer service, you can text us back and a real person will be there to help.

Our team will help you on your keto journey.*

By submitting this form, you agree to receive recurring automated promotional and personalized marketing text messages (e.g. cart reminders) from H.V.M.N. at the cell number used when signing up.

Consent is not a condition of any purchase. Reply HELP for help and STOP to cancel. Msg frequency varies. Msg and data rates may apply. View Terms & Privacy.

Icons/Close/Hover Created with Sketch.

Ring Ring!

We sent a confirmation code to ""

Icons/Close/Hover Created with Sketch.

Seems Like You Really Liked our Sampler!

Unfortunetly we only allow one sampler pack per customer. Pick from our 12 pack options to order more or head over to Shop All to checkout all of our other products.

x12
Keto Food Bar — Chocolate Chunk

Flavor

Chocolate Chunk
Everything Bagel
Mexican Hot Chocolate
Vanilla Shortbread
Variety Pack
(0)
A classic with nut butter, chocolate, and salt.