What research studies have been done using HVMN Ketone?

Authored by Nate Martins and Justin Liau • 
September 25, 2018
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HVMN Ketone is the result 15+ years of research and millions of dollars of funding by DARPA, the NIH and Oxford University. Extensive testing has been devoted to taking the ketone ester research compound (called ‘ΔG,’ or ‘R 1,3-butanediol R 1,3 hydroxybutyrate') to commercialization in HVMN Ketone.

This ketone ester has been extensively tested for safety and efficacy in both animal and human studies.1 After one serving of ketone ester, blood ketone levels can increase up to 3-5 mM. Ketone ester has shown to have effects on metabolism that can improve performance for athletes,2 but can also be useful for general health. The list of possible use cases includes: body composition optimization, obesity, inflammation reduction, treating traumatic brain injury, cognitive improvement or neurological disorders.3

Studies of the ketogenic diet (i.e., studies of endogenous ketosis) date back to the 1920s, when it was first used to treat children with epilepsy.

Research has shown that low-carb, high-fat diets (which trigger the production of ketone bodies) have potential uses in conditions such as diabetes, metabolic syndrome, Parkinson's disease, Alzheimer's disease, and cancer.4 However, there are some downsides to the low carbohydrate diet including difficulties in compliance and some potentially harmful side effects.4

Exogenous ketones like ketone esters, ketone salts and medium chain triglycerides (MCT) may offer a way to induce the benefits of ketosis without requiring adherence to the strict ketogenic diet.5 Exogenous ketone supplementation is a rapidly developing field of research, investigating health and performance benefits of ketone drinks compared to the keto diet.

The research studies are abundant (in both human clinical trials and animal models), and have been conducted using the ketone ester found in HVMN Ketone.

Studies in Human Athletes

Studies in Human Non-Athletes

Studies in Animals

Scientific Citations

1.Clarke, K., Tchabanenko, K., Pawlosky, R., Carter, E., Todd King, M., Musa-Veloso, K., Ho, M., Roberts, A., Robertson, J., Vanitallie, T.B., et al. (2012). Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects. Regul. Toxicol. Pharmacol. 63, 401-408.
2.Cox, P.J., Kirk, T., Ashmore, T., Willerton, K., Evans, R., Smith, A., Murray, Andrew J., Stubbs, B., West, J., McLure, Stewart W., et al. (2016). Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes. Cell Metabolism 24, 1-13.
3.Veech 2014: The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):309-19.
4.Branco AF, Ferreira A, Simões RF, Magalhães-Novais S, Zehowski C, Cope E, Silva AM, Pereira D, Sardão VA, Cunha-Oliveira T. Ketogenic diets: from cancer to mitochondrial diseases and beyond. Eur J Clin Invest. 2016 Mar;46(3):285-98.
5.Stubbs, B.Cox, P.; Evans, R.; Santer, P.; Miller, J.; Faull, O.; Magor-Elliott, S.; Hiyama, S.; Stirling, M.; Clarke, K. (2017). On the metabolism of exogenous ketones in humans. Front. Physiol.
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