Is HVMN Ketone safe?

Authored by Nate Martins and Justin Liau • 
July 11, 2018

HVMN Ketone is a clinically-validated superfuel that can be used to improve training, recovery, and performance. Not only is it safe, its health benefits have been extensively studied.

D-BHB is a natural fuel source the body can produce as well as burn. HVMN Ketone delivers a D-BHB Ester, which provides two equivalents of D-BHB that can be readily metabolized by the body. Read more about ketone supplement fundamentals here.

A stack of HVMN Ketone boxes

Much time and research have been designated to developing the world’s first ketone ester. We take pride in HVMN Ketone and its benefits, which include:

  • Safe, tolerable, side effect free: The D-BHB ester has repeatedly been shown to be safe and well tolerated at several escalating doses. Even at high doses, there are minimal side-effects. 1
  • Optimal BHB: D-BHB ester raises BHB levels higher than ketone salts and works even when taken with a carbohydrate-rich meal.2 The D-BHB ester can reliably raise blood ketones in a dose-dependent way.3 If you take more, you get higher blood BHB.
  • Greater Endurance: D-BHB ester improved endurance performance in a 30-minute cycling test by 2-3% (400m) when taken before exercise with carbohydrate.4
  • Muscle Replenishing: When taken after exercise along with IV glucose, D-BHB ketone ester improved the resynthesis of the storage form of carbohydrate, glycogen.5
  • Muscle Building: When taken after exercise with carbs and protein, the D-BHB ketone ester strongly activated cellular pathways controlling muscle protein synthesis.6
  • Appetite Suppression: D-BHB ketone ester decreases appetite and also the levels of the hunger hormone, ghrelin.7
  • Lowers Blood Glucose: D-BHB ketone ester lowers blood glucose response to an oral glucose tolerance test.8
  • Additional Health Benefits: In a case study of one patient with Alzheimer’s Disease, daily D-BHB ketone ester consumption improved cognitive impairment.9

We're always open to your questions or concerns; feel free to send us a note at: care@hvmn.com

Scientific Citations

1.Clarke, K., Tchabanenko, K., Pawlosky, R., Carter, E., Todd King, M., Musa-Veloso, K., Ho, M., Roberts, A., Robertson, J., Vanitallie, T.B., et al. (2012). Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects. Regul. Toxicol. Pharmacol. 63, 401-408.
2.Stubbs, B.Cox, P.; Evans, R.; Santer, P.; Miller, J.; Faull, O.; Magor-Elliott, S.; Hiyama, S.; Stirling, M.; Clarke, K. (2017). On the metabolism of exogenous ketones in humans. Front. Physiol.
3.Shivva, V., Cox, P.J., Clarke, K., Veech, R.L., Tucker, I.G., and Duffull, S.B. (2016). The Population Pharmacokinetics of d-β-hydroxybutyrate Following Administration of (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate. The AAPS journal, 1-11.
4.Cox, P.J., Kirk, T., Ashmore, T., Willerton, K., Evans, R., Smith, A., Murray, Andrew J., Stubbs, B., West, J., McLure, Stewart W., et al. (2016). Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes. Cell Metabolism 24, 1-13.
5.Holdsworth, D.A., Cox, P.J., Kirk, T., Stradling, H., Impey, S.G., and Clarke, K. (2017). A Ketone Ester Drink Increases Postexercise Muscle Glycogen Synthesis in Humans. Med Sci Sports Exerc.
6.Vandoorne, T., De Smet, S., Ramaekers, M., Van Thienen, R., De Bock, K., Clarke, K., and Hespel, P. (2017). Intake of a Ketone Ester Drink during Recovery from Exercise Promotes mTORC1 Signaling but Not Glycogen Resynthesis in Human Muscle. Front. Physiol. 8, 310.
7.Stubbs BJ, Cox PJ, Evans RD, Cyranka M, Clarke K, De wet H. A Ketone Ester Drink Lowers Human Ghrelin and Appetite. Obesity (Silver Spring). 2018;26(2):269-273.
8.Myette-Cote E, Neudorf H, Rafiei H, Clarke K, Little JP. Prior ingestion of exogenous ketone monoester attenuates the glycaemic response to an oral glucose tolerance test in healthy young individuals. LID - 10.1113/JP275709 [doi]. 2018(1469-7793 (Electronic)).
9.Newport, M.T., VanItallie, T.B., Kashiwaya, Y., King, M.T., and Veech, R.L. (2015). A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association 11, 99-103.
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