How long does HVMN Ketone last?

Authored by Nate Martins and Justin Liau • 
August 6, 2018

HVMN Ketone was engineered to put the body into an almost-immediate state of ketosis, raising blood ketone levels > 0.5 mM (remember, this is different than being ketogenic). 30 minutes after use, your blood ketones will begin to rise, and should continue to be elevated for 4 - 6 hours.1,2

For performance, take HVMN Ketone plus some carbs around 30 minutes before your workout and top up after 1.5 - 2 hours if you’re doing a long training session or race. For recovery, it can expedite glycogen and protein resynthesis for several hours post-workout.

A chart illustrating the benefits of ketosis garnered from HVMN Ketone when compared to MCTs or ketone salts

Obviously, everyone is different. So the length of time for elevated ketone levels will differ from person-to-person, as well as a few external factors–like if you’re exercising or following a ketogenic diet.

If BHB reaches a higher peak, then it will take longer to fall.1 Peak BHB is especially affected by size and lean mass,2 and the amount of physical activity one does. When exercising, the body uses BHB as a fuel and so it disappears from the blood faster.3

When taken before exercise, D-BHB from HVMN Ketone has shown an increase in efficient working muscle by 28% (when compared to carbohydrates alone). Your muscles are doing more work with the same amount of oxygen.4 And because HVMN Ketone affects metabolism fundamentally, there are compounding benefits adding up to superior performance; athletes go ~2% further in a 30-minute time trial.3

A chart illustrating the suboptimal benefits of carbs when compared to carbs plus HVMN Ketone

For recovery, athletes using HVMN Ketone have shown a decrease in the breakdown of intramuscular glycogen and protein during exercise when compared to carbs alone.3 HVMN Ketone can also expedite the resynthesis of glycogen by 60% and protein by 2x when added to your normal carb/protein post-workout fuel.5,6

A graph showcasing the effect of HVMN Ketone plus carbs for optimal post-workout fuel when compared to carbs alone.

What makes HVMN Ketone so effective and long-lasting? Its makeup. HVMN Ketone is an ester comprised of a very bioavailable form of beta-hydroxybutyrate (BHB); it’s 98.24% ketones plus water, which gives it a unique level of purity to quickly and effectively deliver optimal ketone levels for accelerated athletic performance.3,1

Upon consuming HVMN Ketone, the ester is broken into two parts inside the gut, then absorbed. The BHB is quickly released into the blood. The BHB precursor (called butanediol) is taken up by the liver and converted into BHB, which is then released back into the blood.

Measuring blood ketone levels is the best way to see HVMN Ketone at work in your body. Peak ketone levels usually occur between 60-90 minutes post-drink. That said, BHB from HVMN Ketone may trigger beneficial effects on the body that last for some time after BHB has disappeared. BHB can activate anti-inflammatory and antioxidant pathways,7 meaning benefits of HVMN Ketone likely last for longer than the time BHB is present in the blood. This is an active area of research, and HVMN is proud to be on the cutting edge and partnering with world-leading scientists to answer these questions.

Have any questions about how long HVMN Ketone lasts in the body? Feel free to comment below or reach out to care@hvmn.com, and we’ll do our best to answer.

Scientific Citations

1.Stubbs, B.Cox, P.; Evans, R.; Santer, P.; Miller, J.; Faull, O.; Magor-Elliott, S.; Hiyama, S.; Stirling, M.; Clarke, K. (2017). On the metabolism of exogenous ketones in humans. Front. Physiol.
2.Shivva, V., Cox, P.J., Clarke, K., Veech, R.L., Tucker, I.G., and Duffull, S.B. (2016). The Population Pharmacokinetics of d-β-hydroxybutyrate Following Administration of (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate. The AAPS journal, 1-11.
3.Cox, P.J., Kirk, T., Ashmore, T., Willerton, K., Evans, R., Smith, A., Murray, Andrew J., Stubbs, B., West, J., McLure, Stewart W., et al. (2016). Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes. Cell Metabolism 24, 1-13.
4.Sato, K., Kashiw.aya, Y., Keon, C.A., Tsuchiya, N., King, M.T., Radda, G.K., Chance, B., Clarke, K., and Veech, RL. (1995). Insulin, ketone bodies, and mitochondrial energy transduction. FASEB J. 9, 651-658.
5.Holdsworth, D.A., Cox, P.J., Kirk, T., Stradling, H., Impey, S.G., and Clarke, K. (2017). A Ketone Ester Drink Increases Postexercise Muscle Glycogen Synthesis in Humans. Med Sci Sports Exerc.
6.Vandoorne, T., De Smet, S., Ramaekers, M., Van Thienen, R., De Bock, K., Clarke, K., and Hespel, P. (2017). Intake of a Ketone Ester Drink during Recovery from Exercise Promotes mTORC1 Signaling but Not Glycogen Resynthesis in Human Muscle. Front. Physiol. 8, 310.
7.Newman, J.C., and Verdin, E. (2017). Ketone bodies as signaling metabolites. Trends Endocrinol. Metab. 25, 42-52.
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