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KetoneAid vs. H.V.M.N. Ketone Ester

KetoneAid vs. H.V.M.N. Ketone Ester

Authored by Geoffrey Woo • 
September 24, 2019
 • 8 min read
exogenous-ketoneshvmn-ketone-esterketosis

There is only one D-Beta-hydroxybutyrate (D-BHB) Ketone Ester drink that’s FDA GRAS (“generally recognized as safe”) and that’s H.V.M.N. Ketone Ester.

Any other D-BHB Ketone Esters on the market are likely falsely advertising, selling an adulterated product, and/or potentially infringing on intellectual property.

Let us explain why.

The History and Intellectual Property Behind H.V.M.N. Ketone Ester

In the early 2000s, DARPA called for research proposals to develop novel foodstuffs to enhance cognitive and physical performance of US warfighters. The program was called “Metabolic Dominance.”

Professor Kieran Clarke from the University of Oxford and Dr. Richard Veech of the National Institutes of Health (NIH), both experts in metabolism, physiology, and ketosis, won the grant and began a decade-long research program that’s still highly active and ongoing.

The result? DeltaG.

Prof. Clarke and Dr. Veech developed a patented Ketone Ester molecule, binding one D-BHB to another D-BHB precursor in an “ester” molecule form—this is called DeltaG.

DeltaG has many synonyms, depending on scientific or colloquial reference: D-beta-hydroxybutyrate-(R)-1,3 butanediol monoester, D-beta-hydroxybutyrate D 1,3-butanediol Monoester, (R)-3-hydroxybutyl (R)-3-hydroxybutyrate, D-BHB Monoester, D-BHB Ester, D-BHB Ketone Ester, CAS# 1208313-97-6.

Prof. Clarke and Dr. Veech were the first to transform the body’s natural ketone, D-beta-hydroxybutyrate (D-BHB), into a stable, safe ester form suitable as a food in its own right.

Prof. Clarke and Dr. Veech started a company called TdeltaS to develop their research in 2005, and H.V.M.N. partnered exclusively with TdeltaS in 2016 to commercialize DeltaG. Thus, the only legitimate DeltaG D-BHB ketone ester drinks are those made by TdeltaS and H.V.M.N. together.

So What’s KetoneAid?

We’re not really sure, and there is a very limited set of possibilities given the facts stated above.

Differences Between H.V.M.N. Ketone Ester and KetoneAid

Let’s analyze the marketing claims and information behind the two products.

Safety, Transparency, and Rigor

H.V.M.N. Ketone Ester is made up of water, D-beta hydroxybutyrate ester, stevia leaf extract, natural flavors, malic acid, potassium sorbate, and potassium benzoate.

KetoneAid claims to contain D-beta hydroxybutyrate ester, water, allulose (a low-calorie sugar), L-Taurine (.5g, an amino acid commonly added to commercial energy drinks like Red Bull and Monster), organic stevia, natural flavors, and potassium sorbate.

While the ingredient lists may look similar, the rigor, transparency, and data to support the ingredient list claims are wildly different.

According to its website, KetoneAid began to make “small batches of the purest ketone ever tested.” But how does KetoneAid substantiate this claim?

As far as we can tell in the public record, KetoneAid doesn’t produce any batch-specific certificates of analysis (CoAs), 3rd party analytical results, or product specification sheets and safety data sheets. One can speculate whether this lack of transparency is due to one or more of the following factors: lack of understanding on how to operate a first-class nutrition business, lack of resources to obtain 3rd party validation, or the potential presence of adulterants in the product unapproved for use in the food supply.

These 3rd party, analytical documents are really table stakes for any sort of food or supplement supplier. When questioned on Amazon.com, KetoneAid does not directly address product safety and quality standards:

An image of a comment on Amazon between KetoneAid and an inquiring customer

On the other hand, H.V.M.N. has done extensive testing on our H.V.M.N. Ketone Ester. We post our CofAs online for public scrutiny and viewing. Because our drink is used extensively in professional sport, we additionally screen every single batch for banned substances with a highly reputable World Anti Doping Agency (WADA)-compliant testing facility. We publicly share these results and allow everyone to scrutinize our data because we stand behind our product’s quality, safety, and rigor.

Research

Multiple on-going research efforts are currently underway to further refine and elucidate our understanding of how to best use H.V.M.N. Ketone Ester for different applications.

DeltaG, the main ingredient in H.V.M.N. Ketone Ester, has been used in numerous clinical trials. This list is extensive; DeltaG has been used in over two dozen research studies. And H.V.M.N. Ketone Ester has been supplied to a number of groups currently conducting research using the product specifically, so we expect a number of papers crediting H.V.M.N. as the supplier in the coming months and years.

KetoneAid has been used in one,1 and the authors subsequently now use H.V.M.N. Ketone Ester for their research. Why? H.V.M.N. provides CoAs and guarantees purity of product for scientific integrity and accuracy.

Price

H.V.M.N. Ketone Ester is sold in a three-pack (containing three bottles) for $99. You know what you’re getting is the real deal, validated by 3rd party audits and trusted by the best athletes and performers in the world.

You can buy KetoneAid as a set of four large trainer bottles ($1,280), one single trainer bottle ($320), three small bottles similar ($120) or one small bottle for the price of $43. But what are you getting? It’s hard to know, because KetoneAid doesn’t have any reports and studies on its product.

Don't Settle

The facts across the board are clear. H.V.M.N. is trusted by the world’s best. Other 'competitive' products on the market are unreliable at best and unsafe at worst. You can further explore the deep history and provenance of DeltaG and H.V.M.N. Ketone Ester here.

Further Learning

Now we’re clear about the stories of H.V.M.N. Ketone Ester and KetoneAid, let’s discuss why ketosis, ketone esters, and exogenous ketones are so promising, both from a science and also a health, performance, and longevity perspective.

What is Ketosis?

Ketosis is a metabolic state where ketone bodies are present in the human body. Generally, this is agreed upon to be ketone levels present in the blood at levels above 0.5mM.2

The human body evolved to be able to enter a state of ketosis. When our ancestors were out on long hunts, we needed some source of fuel to function. Carbohydrates are used for a quick energy boost, but between meals, we didn’t have any as energy sources. What did we have? Large stores of fat (when compared to carbs).

The problem? The brain can’t use fat for fuel (it loves carbohydrates). So we evolved to be able to tap into those fat stores and provide energy for the brain in the form of ketones, produced by the liver—a hyper-efficient fuel source for both the brain and the body.3 Ketones can cross the blood-brain barrier.4 And for this reason, many people cite improved mental performance while in ketosis.

You can get into ketosis through a variety of means today. Usually a person enters a state of ketosis through these three mechanisms:

  • Fasting
  • Eating a low-carb, high-fat, moderate-protein ketogenic diet
  • Consuming exogenous ketones like H.V.M.N. Ketone Ester

The ketogenic diet is one of the most popular ways to enter ketosis (and is lauded for its weight loss and fat-burning capabilities). Fasting is also popular, and many people who practice a keto diet will also employ intermittent fasting because they both result in endogenous ketosis.

But there’s also another way to enter ketosis: consuming exogenous ketones. This is a relatively new strategy, in which the ketones come from an external source.

Ketone bodies typically describe beta-hydroxybutyrate (BHB), the primary ketone body; it’s the ketone body circulating at highest levels in the blood, with other types of ketones in lower amounts.5

Acetoacetate and acetone are also ketone bodies, but are downstream metabolic products of BHB. Ketone bodies can be metabolized by mitochondria to produce ATP, the energy currency of life, like other metabolic substrates like glucose. However, ketone bodies don’t require insulin and are highly efficient.

Emerging science over the last couple years also suggests that BHB is a signaling molecule. This means that presence of BHB in the body might signal, mediate, and control some of the metabolic benefits that are ascribed to fasting, caloric restriction, or ketogenic diets.

How to Achieve Ketosis

Endogenous ketosis is the body’s natural processes to enter ketosis. This only happens in a carbohydrate-restricted state which can be created through fasting or a ketogenic diet. This means the body is converting its own fat reserves into ketone bodies.

Exogenous ketosis is delivering external ketone bodies directly into the body through foods or supplements like H.V.M.N. Ketone Ester. In this case, a person can have carbohydrates and ketones at the same time, which is not normally possible in the wild.

The differences between endogenous and exogenous ketosis is still an active, ongoing area of research.

Both paradigms result in ketone bodies in the system replete with effects of ketone metabolism and ketone signaling. However there are several key differences.

Exogenous ketones induce the state much more rapidly. With H.V.M.N. Ketone Ester, you can get into a deep state of ketosis within 30 minutes where the same level of ketosis would take multiple days of fasting or a week or two of a ketogenic diet.

Also unique to exogenous ketosis is the ability to still have carbohydrates in the system. This is not possible through endogenous ketosis because the context of no-carbohydrate is required to signal the liver to produce ketone bodies from stored fat.

Lastly, with H.V.M.N. Ketone Ester, you can dose-adjust how much ketones you want in your body through consumption. With endogenous ketosis, you can’t really control how much ketone bodies the body produces.

Because of these use cases of exogenous ketones, many scientists, athletes, and serious health enthusiasts have been looking at what are the best exogenous ketone types to use.

There are limitations or drawbacks with ketone salts. Plus, it’s required to onboard a large amount of salt to achieve only moderate increases blood ketone levels.6,7

And there’s different use cases and value for things like medium-chain triglycerides (MCT). These MCTs are fats that are ketogenic—meaning they’re readily converted into ketone bodies by the liver.

Within the “medium-chain” length of triglyceride, there are even more optimal chain lengths than others. Caproic acid (C6) is the shortest, generally not found in supplements. Capric acid (C10) is found in coconut oil and some forms on animal milk, and may have antibacterial properties.8,9 Lauric acid (C12) behaves almost like a long-chain fatty acid, and may have skincare benefits.10,11

Caprylic acid (C8) is known as the most ketogenic form of MCT. It converts into ketones faster than any other type of MCT, and helps reduce gut inflammation.12,13,14 This is the type of MCT you should be looking for in your supplements, which is exactly why H.V.M.N. MCT Oil Powder uses only 100% C8.

But the holy grail of exogenous ketones is H.V.M.N. Ketone Ester. It’s by far the most potent and rapid way to induce deep ketosis, raising blood ketone levels to 3mM - 6mM.6,15,16,17 You can learn all about ketone esters on the H.V.M.N. Podcast here.

H.V.M.N. Ketone Ester has been employed to improve athletic performance as well. It has been used to break world records, win gold medals and championships, improve recovery, and help a myriad of people with their health and wellness goals. Customers include Tour de France cyclists, NFL teams, MLB teams, the US Military, world championship fighters, and more.

There’s a broad swathe of academic literature that’s constantly expanding about how being in ketosis might be a helpful nutritional state. Literature suggests utility both for medical conditions as well as performance use cases.

Customers of H.V.M.N. use our ketone ester drink for sports performance & recovery, a cognitive boost, metabolic stabilization and control, and for potential longevity benefits of ketone signaling.

Ways to Test for Ketosis

The great thing about H.V.M.N. Ketone Ester is that you can directly test if BHB is actually being delivered into your body. There’s a number ways of test ketosis. One can use a blood, urine, or breath as different ways to test ketosis.

The most studied and most accurate way to measure and benchmark ketosis is through blood.

Virtually all clinical trials use blood as the definitive way to measure ketosis, so it’s the most widely used standard. Urine and breath tests usually measure excreted acetoacetate, which is a byproduct of BHB metabolism. These are valid ways to measure ketosis but is not as standardized with blood.

When drinking one serving of H.V.M.N. Ketone Ester, you can expect to reach 3mM - 5mM of BHB within an hour for a 70kg (or 154lb) person. That level of ketosis would usually take multiple days of fasting or a very strict ketogenic diet to reach.

The proof is in the test. If you can’t measure it, it’s hard to tell if it works. With H.V.M.N. Ketone Ester, the data is right there for you to test.

Choosing an Exogenous Ketone

There's can be a lot of confusing information when selecting an exogenous ketone supplement. Find one that you can trust, from a reputable company driven by science. And make sure to research your specific needs. What are you looking for in a ketone supplement? Increased endurance? Improved cognition? A ramp up to natural ketone production? These are all considerations you need to consider before selecting the best ketone supplement for you.

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Scientific Citations

1.Evans M, Egan B. Intermittent Running and Cognitive Performance after Ketone Ester Ingestion. Med Sci Sports Exerc. 2018;50(11):2330-2338.
2.The Art and Science of Low Carbohydrate Living: An Expert Guide to Making the Life-saving Benefits of Carbohydrate Restriction Sustainable and Enjoyable. Jeff Volek, Phd Stephen D. Phinney MD, Rd Jeff S. Volek Phd, Stephen D. Phinney. Beyond Obesity, 2011.
3.Cahill, G.F., Jr. (2006). Fuel metabolism in starvation. Annu Rev Nutr 26, 1-22.
4.Hasselbalch SG, Knudsen GM, Jakobsen J, Hageman LP, Holm S, Paulson OB. Blood-brain barrier permeability of glucose and ketone bodies during short-term starvation in humans. Am J Physiol. 1995;268(6 Pt 1):E1161-6.
5.Laffel, L. (1999). Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab. Res. Rev. 15, 412-426.
6.Stubbs, B.Cox, P.; Evans, R.; Santer, P.; Miller, J.; Faull, O.; Magor-Elliott, S.; Hiyama, S.; Stirling, M.; Clarke, K. (2017). On the metabolism of exogenous ketones in humans. Front. Physiol.
7.O’Malley, T., Myette-Cote, E., Durrer, C., and Little, J.P. (2017). Nutritional ketone salts increase fat oxidation but impair high-intensity exercise performance in healthy adult males. Applied Physiology, Nutrition, and Metabolism, 1-5.
8.Bergsson G, Arnfinnsson J, Steingrímsson o, Thormar H. In vitro killing of Candida albicans by fatty acids and monoglycerides. Antimicrob Agents Chemother. 2001;45(11):3209-12.
9.Francois CA, Connor SL, Wander RC, Connor WE. Acute effects of dietary fatty acids on the fatty acids of human milk. Am J Clin Nutr. 1998;67(2):301-8.
10.Nakatsuji T, Kao MC, Fang JY, et al. Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris. J Invest Dermatol. 2009;129(10):2480-8.
11.Aziz, Azila & Sarmidi, Mohamad & Aziz, R & mohamed noor, Norhayati. (2013). The Effect of Virgin Coconut Oil Loaded Solid Lipid Particles (VCO-SLPs) on Skin Hydration and Skin Elasticity. Jurnal Teknologi. 62. 39-43.
12.Vandenberghe, C., St-Pierre, V., Pierotti, T., Fortier, M., Castellano, C.-A., and Cunnane, S.C. (2017). Tricaprylin Alone Increases Plasma Ketone Response More Than Coconut Oil or Other Medium-Chain Triglycerides: An Acute Crossover Study in Healthy Adults. Current Developments in Nutrition 1.
13.Nair NKM, Joy J, Vasudevan P. Antibacterial Effect of Caprylic Acid and Monocaprylin on Major Bacterial Mastitis Pathogens. Journal of Dairy Science. 2005;88(10):3488-3495. doi.org/10.3168/jds.S0022-0302(05)73033-2.
14.Hoshimoto A, Suzuki Y, Katsuno T, Nakajima H, Saito Y. Caprylic acid and medium-chain triglycerides inhibit IL-8 gene transcription in Caco-2 cells: comparison with the potent histone deacetylase inhibitor trichostatin A. Br J Pharmacol. 2002;136(2):280-6.
15.Cox, P.J., Kirk, T., Ashmore, T., Willerton, K., Evans, R., Smith, A., Murray, Andrew J., Stubbs, B., West, J., McLure, Stewart W., et al. (2016). Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes. Cell Metabolism 24, 1-13.
16.Shivva, V., Cox, P.J., Clarke, K., Veech, R.L., Tucker, I.G., and Duffull, S.B. (2016). The Population Pharmacokinetics of d-β-hydroxybutyrate Following Administration of (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate. The AAPS journal, 1-11.
17.Clarke, K., Tchabanenko, K., Pawlosky, R., Carter, E., Todd King, M., Musa-Veloso, K., Ho, M., Roberts, A., Robertson, J., Vanitallie, T.B., et al. (2012). Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects. Regul. Toxicol. Pharmacol. 63, 401-408.
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These statements have not been evaluated by the FDA. Our products are not intended to diagnose, treat, cure, or prevent any disease.

© 2019 HVMN Inc. All Rights Reserved. H.V.M.N.®, Health Via Modern Nutrition™, Nootrobox®, Rise™, Sprint®, Yawn®, Kado™, and GO Cubes® are registered trademarks of HVMN Inc. ΔG® is a trademark of TΔS® and used under exclusive license by HVMN Inc.

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These statements have not been evaluated by the FDA. Our products are not intended to diagnose, treat, cure, or prevent any disease.

© 2019 HVMN Inc. All Rights Reserved. H.V.M.N.®, Health Via Modern Nutrition™, Nootrobox®, Rise™, Sprint®, Yawn®, Kado™, and GO Cubes® are registered trademarks of HVMN Inc. ΔG® is a trademark of TΔS® and used under exclusive license by HVMN Inc.