Vinpocetine

Pharmacology

Vinpocetine is derived from the periwinkle plant, is readily bioavailable and crosses the blood brain barrier. There is preliminary evidence to suggest vinpocetine can counteract neural inflammation and improve reaction time, working memory and attention.

vinpocetine_structure

Structure of Vinpocetine

Vinpocetine is absorbed when taken through oral ingestion, or when applied topically. Interestingly, Vinpocetine appears to accumulate in particular brain regions. Specifically, the thalamus (central relay for motor and sensory coordination, also involved in the regulation of alertness and sleep), basal ganglia ( a group of structures linked to the thalamus involved in coordinating motor function), putamen, and visual cortex.

Vinpocetine appears to have multiple molecular pathways with which it interacts. However, the most significant appear to be its effect on cyclic nucleotide metabolism and subsequent vascular relaxation. Vinpocetine has been shown to inhibit calcium-dependent phosphodiesterase enzymes, which are involved in producing cyclic GMP - a molecular that regulates blood vessel tone or stiffness.1

Effects on attention and working memory

In a study of 12, healthy, female volunteers, 40 mg of Vinpocetine improved memory, using the Sternberg technique. The Sternberg test involves the presentation of a list of items to memorize, followed by a memory maintenance period, during which these items must be kept in memory. Though the number of subjects here is small and the finding is un-replicated, this evidence suggests there might be an improvement in working memory and attention with the administration of vinpocetine.2

Another study of 24 healthy volunteers, investigated study found that Ginkgo biloba (40 mg) and Vinpocetine (10 mg) taken together significantly decreased reaction times for a working memory task after the combination was consumed for 14 days.3The accumulation of vinpocetine in motor portions of the brain suggests that this reaction time increases may be a result of enhanced motor function.

How to take

Vinpocetine is taken in the daily dosage range of 15-60mg, divided into three daily doses with meals. The standard low dose is 5mg at each of these three meals, with 20mg at each meal being seen as the higher end of efficacy. These doses are taken for the purposes of neuroprotection, enhancing cerebral blood flow for acute enhanced cognitive performance, and for reducing the rate of cognitive decline.

Editorial Opinion

The evidence suggests vinpocetine supplementation improves blood flow to the brain, however, the evidence for cognitive enhancement is not definitive and requires further investigation. The accumulation of vinpocetine in motor regions of the brain, coupled with evidence that it reduces vascular tone to increase blood flow, suggests vinpocetine may improve motor function through increasing activity of motor-relevant brain regions. However, much more research is needed on the functional effects of vinpocetine in the brain and any purported improvements in mental and physical performance.

Emails worth reading.

Bi-weekly emails from the HVMN team. We'll send you the most compelling and exciting updates, stories, and research in the world of human enhancement and biohacking.

HVMN Co-founders Michael Brandt and Geoffrey Woo