Gamma-Aminobutyric acid (GABA) is the most prevalent inhibitory neurotransmitters in the human central nervous system. GABA plays a wide variety of roles in many cognitive processes, however,

Pharmacology of GABA

GABA has many interesting properties in the nervous system. However, it is unable to cross the blood-brain-barrier when ingested orally. As a result, much GABA supplementation has no effects on the central nervous system.1There may also be an effect of age on GABA uptake, as one study in rats demonstrated neonatal animals more readily uptake radio-labelled GABA.2

There is some data to suggest that GABA supplementation may upregulate certain forms of growth hormone and that this release is dependent on dopamine signaling in the pituitary gland.3However, that study only saw increases in certain forms of growth hormone (irGH and ifGH), that are not well understood. More work is needed to determine how different isoforms of growth hormone impact exercise efficiency and responses in humans4

Editorial Opinion

Due to its inability to cross the blood-brain-barrier, we do not recommend GABA supplementation for cognitive enhancement. There is preliminary data around GABA and growth hormone. However, there is much more work to be done in this field before recommendations can be made.

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