Known associations of genetic variants are shown below. Here, genes with an association with neuroticism are shown. A genetic variant may have a high association of propensity (i.e., odds ratio > 1) for neuroticism. On the other hand, a genetic variant that has an association of protection (i.e., odds ratio < 1), would confer higher propensity for positivity.
There are a number of candidate genes that may be implicated in traits for neuroticism, discovered by GWAS studies. Future research should dive into dissecting out variants at these targets:
Luciano, M., Huffman, J. E., Arias‐Vásquez, A., Vinkhuyzen, A. A., Middeldorp, C. M., Giegling, I., ... & Ke, X. (2012). Genome‐wide association uncovers shared genetic effects among personality traits and mood states. American Journal of Medical Genetics part B: Neuropsychiatric Genetics, 159(6), 684-695.
De Moor, M. H., Van Den Berg, S. M., Verweij, K. J., Krueger, R. F., Luciano, M., Vasquez, A. A., ... & Gordon, S. D. (2015). Meta-analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder. JAMA psychiatry, 72(7), 642-650.
Karlsson, R., Graae, L., Lekman, M., Wang, D., Favis, R., Axelsson, T., ... & Paddock, S. (2012). MAGI1 copy number variation in bipolar affective disorder and schizophrenia. Biological psychiatry, 71(10), 922-930.
Ferentinos, P., Rivera, M., Ising, M., Spain, S. L., Cohen-Woods, S., Butler, A. W., ... & Jones, I. (2014). Investigating the genetic variation underlying episodicity in major depressive disorder: Suggestive evidence for a bipolar contribution. Journal of affective disorders, 155, 81-89.
Etain, B., Mathieu, F., Rietschel, M., Maier, W., Albus, M., Mckeon, P., ... & Bellivier, F. (2006). Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I early-onset proband: supportive evidence for linkage at 3p14. Molecular psychiatry, 11(7), 685-694.
Bae, H. T., Sebastiani, P., Sun, J. X., Andersen, S. L., Daw, E. W., Terracciano, A., ... & Perls, T. T. (2013). Genome-wide association study of personality traits in the long life family study. Frontiers in genetics, 4.
Terracciano, A., Sanna, S., Uda, M., Deiana, B., Usala, G., Busonero, F., ... & Distel, M. A. (2010). Genome-wide association scan for five major dimensions of personality. Molecular psychiatry, 15(6), 647-656.
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